BNP Signal Peptide is Protective in Ischaemia Reperfusion Injury
نویسندگان
چکیده
منابع مشابه
Is adalimumab protective in ischemia-reperfusion injury in lung?
Objective(s): Increasing cytokines and reactive oxygen species (ROS) during ischemia reperfusion (I-R) leads to the lung damage. Adalimumab (Ada) is a potent tumor necrosis factor-alpha (TNF-α) inhibitor agent. We aimed to evaluate whether Ada would prevent the lung tissue from damage development over the I-R process. Materials and Methods:Twenty seven Wistar albino male rats were divided into...
متن کاملEndothelial protective effect of stobadine on ischaemia/reperfusion-induced injury.
The aim of the present study was to evaluate the influence of the antioxidant stobadine on changes in the reactivity of the rat abdominal aorta induced by ischaemia and reperfusion (I/R). In anaesthetized male rats, in vivo ischaemia was elicited by occlusion of the abdominal aorta for 18 hours; reperfusion lasted 30 minutes. The aortal rings were taken from the reperfused portion. Decreased re...
متن کاملis adalimumab protective in ischemia-reperfusion injury in lung?
objective(s): increasing cytokines and reactive oxygen species (ros) during ischemia reperfusion (i-r) leads to the lung damage. adalimumab (ada) is a potent tumor necrosis factor-alpha (tnf-α) inhibitor agent. we aimed to evaluate whether ada would prevent the lung tissue from damage development over the i-r process. materials and methods:twenty seven wistar albino male rats were divided into ...
متن کاملDirect cardiac actions of erythropoietin (EPO): effects on cardiac contractility, BNP secretion and ischaemia/reperfusion injury.
EPO (erythropoietin) has recently been shown to have protective actions upon the myocardium; however, the direct effects of EPO upon cardiac contractile and secretory functions are unknown and the signalling mechanisms are not well defined. In the present study, we provide the first evidence of direct cardiac contractile actions of EPO. In isolated perfused Sprague-Dawley rat hearts, a 30 min i...
متن کاملVascular ischaemia and reperfusion injury.
Although restoration of blood flow to an ischaemic organ is essential to prevent irreversible tissue injury, reperfusion per se may result in a local and systemic inflammatory response that may augment tissue injury in excess of that produced by ischaemia alone. Cellular damage after reperfusion of previously viable ischaemic tissues is defined as ischaemia-reperfusion (I-R) injury. I-R injury ...
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ژورنال
عنوان ژورنال: Heart, Lung and Circulation
سال: 2013
ISSN: 1443-9506
DOI: 10.1016/j.hlc.2013.05.077